Brazilian Journal of Anesthesiology
https://bjan-sba.org/article/doi/10.1590/S0034-70942012000400012
Brazilian Journal of Anesthesiology
Review Article

Sedação paliativa do paciente terminal

Palliative sedation of terminally ill patients

Fabíola Leite Nogueira; Rioko Kimiko Sakata

Downloads: 1
Views: 1186

Resumo

JUSTIFICATIVA E OBJETIVOS: Apesar da ampla discussão sobre o assunto na literatura médica, a maioria das questões continua não respondida devido à falta de definições e orientações claras, além do grande número de contradições na literatura. O objetivo desta revisão é tentar verificar a melhor forma de sedação dos pacientes com câncer. CONTEÚDO: Foram colhidos dados sobre sedação: definições, classificações, principais manifestações e critérios para indicação, seleção de medicamentos usados, os medicamentos mais empregados, doses e vias, duração da sedação, suporte nutricional e hidratação durante a sedação e sedação domiciliar. CONCLUSÕES: Apesar de nos últimos anos a sedação paliativa estar sendo considerada prática médica normal, ainda existem várias lacunas em nossa compreensão atual. Não existe consenso sobre quais os fármacos padrões, manutenção ou não de alimentação, ingestão de líquidos, e hidratação. Além disso, faltam esclarecimentos éticos sobre possíveis efeitos no encurtamento da vida, e o processo de tomada de decisão.

Palavras-chave

Assistência Paliativa, DOENÇAS, Câncer, SEDAÇÃO, Profunda

Abstract

BACKGROUND AND OBJECTIVES: Although there is extensive discussion on the subject in medical literature, most of the questions still unanswered due to the lack of clear definitions and guidelines, in addition to a large number of contradictions in literature. The aim of this review is to try to determine the best form of sedation for patients with cancer. CONTENT: The following data on sedation were collected: definitions, classifications, major events and indication criteria, selection of drugs used, drugs most used, doses and routes, duration of sedation, nutritional support and hydration during sedation, and sedation at home. CONCLUSIONS: Although in recent years palliative sedation is being considered a normal medical practice, there are still many gaps in our current understanding. There is no consensus about which are the standard drugs, maintenance or not of food, fluid intake, and hydration. Moreover, there is no ethical clarification on possible life-shortening effects and decision-making process.

Keywords

Deep Sedation, Neoplasms, Palliative Care

Referências

Muller-Busch HC, Andres I, Jehser T. Sedation in palliative care- a critical analysis of 7 years experience. BMC Palliat Care. 2003;2(1).

Gonçalves JAF. Sedation and Expertise in Palliative Care. J Clin Onc. 2006;24(25):44-45.

Verkerk M, van Wijlick E, Legemaate J. A national guideline for palliative sedation in the Netherlands. J Pain Symptom Manage. 2007;34(6):666-670.

Claessens P, Menten J, Schotsmans P. Palliative sedation: A review of the research literature. J Pain Symptom Manage. 2008;36(3):310-333.

Kettler D, Nauck F. Palliative care and involvement of anaesthesiology: current discussions. Curr Opin Anaesthesiol. 2010;23:173-176.

Hoven B. What to do when a competent ICU patient does not want to live anymore but is dependent on life-sustaining treatment?: Experience from the Netherlands. Intensive Care Med. 2010;36:2145-2148.

Morita T, Tsuneto S, Shima Y. Definition of sedation for symptom relief: a systematic literature review and a proposal of operational criteria. J Pain Symptom Manage. 2002;24(4):447-453.

De Graeff A, Dean M. Palliative sedation therapy in the last weeks of life: a literature review and recommendations for standards. J Palliat Med. 2007;10(1):67-85.

Claessens P, Menten J, Schotsmans P. Palliative sedation, not slow euthanasia: A prospective, longitudinal study of sedation in Flemish Palliative Care Units. J Pain Symptom Manage. 2010.

Vitetta L, Kenner D, Sali A. Sedation and analgesia-prescribing patterns in terminally ill patients at the end of life. Am J Hosp Pall Care. 2005;22:465-473.

Sykes N, Thorns A. Sedative use in the last week of life and the implications for end-of-life decision making. Arch Intern Med. 2003;163:341-344.

Mercadante S, Intravaia G, Villari P. Controlled sedation for refractory symptoms in dying patients. J Pain Symptom Manage. 2009;37(5):771-779.

Mercadante S, Porzio G, Valle A. Palliative Sedation in Patients with Advanced Cancer Followed at Home: A Systematic Review. J Pain Symptom Manage. 2011.

Alonso-Babarro A, Varela-Cerdeira M, Torres-Vigil I. At-home palliative sedation for end-of-life cancer patients. Palliat Med. 2010;24(5):486-492.

Rosengarten OS, Lamed Y, Zisling T, Feigin A, Jacobs JM. Palliative sedation at home. J Palliat Care. 2009;25(1):5-11.

Elsayem A, Curry Iii E, Boohene J. Use of palliative sedation for intractable symptoms in the palliative care unit of a comprehensive cancer center. Support Care Cancer. 2009;17(1):53-59.

Morita T, Chinone Y, Ikenaga M. Ethical validity of palliative sedation therapy: a multicenter, prospective, observational study conducted on specialized palliative care units in Japan. J Pain Symptom Manage. 2005;30(4):308-319.

Kohara H, Ueoka H, Takeyama H. Sedation for terminally ill patients with cancer with uncontrollable physical distress. J Palliat Med. 2005;8(1):20-25.

Santasuanan AV, Jiménez NC, Salvador S. The final week of life in an acute care hospital: review of 401 consecutive patients. Rev Esp Geriatr Gerontol. 2008;43(5):284-290.

Marín JLM, Reta IS, Campos RAI. Treatment recommendations at the end of the life of the critical patient. Med Intens. 2008;32(3):121-133.

Russell JA, Williams MA, Drogan O. Sedation for the imminently dying: survey results from the AAN Ethics Section. Neurology. 2010;74(16):1303-1309.

Rousseau P. Palliative sedation in the management of refractory symptoms. J Support Oncol. 2004;2:181-186.

Stiel S, Krumm N, Schroers O. Indications and use of benzodiazepines in a palliative care unit. Schmerz. 2008;22(6):665-671.

De Graeff A, Dean M. Palliative sedation therapy in the last weeks of life: a literature review and recommendations for standards. J Pall Med. 2007;10:67-85.

Rosengarten OS, Lamed Y, Zisling T. Palliative sedation at home. J Palliat Care. 2009;25(1):5-11.

Krakauer EL, Penson RT, Truog RD. Sedation for intractable distress of a dying patient: acute palliative care and the principle of double effect. Oncologist. 2000;5:53-62.

Mercadante S, Ferrera P, Casuccio A. The use of opioids in the last week of life in an acute palliative care unit. Am J Hosp Palliat Care. 2010;27(8):514-517.

Hasselaar JGJ, Verhagen SCAHHVM, Wolff AP. Changed patterns in Dutch palliative sedation practices after the introduction of a National Guideline. Arch Intern Med. 2009;169(5):430-437.

Von Roenn JH, Von Gunten CF. Are We Putting the Cart Before the Horse?. Arch Intern. 2009;169(5).

Morita T, Tsunoda J, Inoue S, Chihara S. Effects of high dose opioids and sedatives on survival in terminally ill cancer patients. J Pain Symptom Manage. 2001;21(4):281-289.

Berger JM, Ryan A, Vadivelu N. Ketamine-fentanyl-midazolam infusion for the control of symptoms in terminal life care. Am J Hosp Palliat Care. 2000;17(2):127-132.

Okon T. Ketamine: an introduction for the pain and palliative medicine physician. Pain Phys. 2007;10:493-500.

Carter MJ, Thomas S, Forbes K. Ketamine: does it have a role in palliative sedation?. J Pain Symptom Manage. 2008;36:1-3.

Herndon CM, Zimmerman E. High-dose propofol drip for palliative sedation: a case report. Am J Hosp Palliat Care. 2008;25(6):492-495.

McWilliams K, Keeley PW, Waterhouse ET. Propofol for terminal sedation in palliative care: a systematic review. J Palliat Med. 2010;13(1):73-76.

Sykes N, Thorns A. Sedative use in the last week of life and the implications for end-of-life decision making. Arch Intern Med. 2003;163(3):341-344.

Morita T, Chinone Y, Ikenaga M. Efficacy and safety of palliative sedation therapy: a multicenter, prospective, observational study conducted on specialized palliative care units in Japan. J Pain Symptom Manage. 2005;30(4):320-328.

Américo AFQ. As últimas 48 horas de vida. Manual de Cuidados Paliativos. 2010:290-298.

Hawryluck LA, Harvey WR, Lemieux-Charles L, Singer PA. Consensus guidelines on analgesia and sedation in dying intensive care unit patients. BMC Med Ethics. 2002;3:1-9.

Quill TE, Lo B, Brock DW. Palliative options of last resort: a comparison of voluntarily stopping eating and drinking, terminal sedation, physician-assisted suicide, and voluntary active euthanasia. JAMA. 1997;278:2099-2104.

Craig GM. On withholding nutrition and hydration in the terminally ill: has palliative medicine gone too far?. J Med Ethics. 1994;20:139-143.

Porzio G, Aielli F, Verna L. Efficacy and safety of deep, continuous palliative sedation at home: a retrospective, single-institution study. Support Care Cancer. 2010;18:77-81.

5dd2abda0e8825b57bc63493 rba Articles
Links & Downloads

Braz J Anesthesiol

Share this page
Page Sections