Brazilian Journal of Anesthesiology
https://bjan-sba.org/article/doi/10.1590/S0034-70942012000100008
Brazilian Journal of Anesthesiology
Scientific Article

Prevalência de sinais de sensibilidade ao látex em pacientes com mielomeningocele submetidos a múltiplos procedimentos cirúrgicos

Prevalence of sensitivity signals to latex in meningomyelocele patients undergoing multiple surgical procedures

Wilson Shi Chia Yeh; Priscila Rivoli Kiohara; Iracy Silvia Corrêa Soares; Maria José Carvalho Carmona; Flavio Trigo Rocha; Clovis Eduardo Santos Galvão

http://dx.doi.org/10.1590/S0034-70942012000100008 Braz J Anesthesiol, vol.62, n1, p.59-62, 2012
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Resumo

JUSTIFICATIVA E OBJETIVOS: O número de pacientes alérgicos ao látex vem aumentando significativamente. É essencial reconhecê-los para preve nir e aplicar o tratamento adequado. O objetivo do estudo foi avaliar a prevalência de alergia ao látex em pacientes com mielomeningocele. MATERIAIS E MÉTODOS: Foram avaliados, retrospectivamente, os prontuários médicos de pacientes com diagnóstico de mielomeningocele no período de janeiro de 2002 a dezembro de 2007. Os pacientes foram agrupados em alérgicos e não alérgicos. A comparação dos grupos em relação ao gênero foi feita pelo teste do Qui-quadrado, pelo teste t de Student em relação à idade, e o teste de Mann-Whitney para comparação entre os grupos em relação as manifestações clínicas de alergia, número de procedimentos sob anestesia, de internações hospitalares e de cateterizações vesicais. RESULTADOS: O número médio de procedimentos sob anestesia foi de 7 no grupo com alergia e 4 no grupo sem alergia, sendo esta diferença estatisticamente significante (p = 0,028). O número médio de internações hospitalares foi de 4,5 no grupo com alergia e 3,4 no grupo sem alergia e a média de cateterização vesical foi 24,5 nos alérgicos e 21,7 nos não alérgicos. CONCLUSÕES: Os pacientes portadores de mielomeningocele submetidos a múltiplos procedimentos sob anestesia apresentam alto risco de desenvolvimento de sinais clínicos de alergia ao látex. Há necessidade de que pacientes com diagnóstico de mielomeningocele sejam submetidos exclusivamente a procedimentos latex-free, evitando o alto risco de sensibilização e suas complicações. Testes específicos para avaliação da sensibilização, marcadores genéticos e relação látex-fruta poderão contribuir para melhor entendimento dos fatores de risco relacionados à alergia ao látex e formas de prevenção

Palavras-chave

COMPLICAÇÕES, Mielomeningocele

Abstract

BACKGROUND AND OBJECTIVES: The number of patients allergic to latex has increased significantly. It is crucial to recognize the cases in order to prevent and apply adequate treatment. The objective of this study was to evaluate the prevalence of allergy to latex in meningomyelocele patients. MATERIALS AND METHODS: A retrospective evaluation of medical records of patients with meningomyelocele diagnosis from January 2002 to December 2007 was conducted. Patients were grouped into allergics and non-allergics. The comparison of groups for gender was made by the Chi-Squared test, the Student's t test was used to compare age, and Mann-Whitney test was used to compare groups for clinical manifestations of allergy, number of procedures under anesthesia, hospital admissions and vesical catheterizations. RESULTS: The mean number of procedures under anesthesia was 7 in the group with allergy and 4 in the group without allergy; this difference was statistically significant (p = 0.028). The mean number of hospital admissions was 4.5 in the group with allergy and 3.4 in group without allergy and mean vesical catheterization was 24.5 in allergic patients and 21.7 in non allergic ones. CONCLUSIONS: Meningomyelocele patients undergoing multiple procedures under anesthesia have high risk of developing clinical signals of allergy to latex. It is necessary that patients with meningomyelocele diagnosis should undergo exclusively latex-free procedures, avoiding high risk of sensitization and its complications. Specific tests to evaluate sensitization, genetic markers and latex-fruit relationship may contribute to a better understanding of risk factors related to allergy to latex and ways to prevent it

Keywords

Perioperative Care, Latex hypersensitivity, Meningomyelocele

References

Hepner DL, Castells MC. Latex allergy: an update. Anesth Analg. 2003;96(4):1219-1229.

Monitto CL, Hamilton RG, Levey E. Genetic predisposition to natural rubber latex allergy differs between health care workers and high-risk patients. Anesth Analg. 2010;110(5):1310-1317.

Allarcon JB, Malito M, Linde H. Latex allergy. Rev Bras Anestesiol. 2003;53(1):89-96.

Sparta G, Kemper MJ, Gerber AC. Latex allergy in children with urological malformation and chronic renal failure. J Urol. 2004;171(4):1647-1649.

Lebenbom-Mansour MH, Oesterle JR, Ownby DR. The incidence of latex sensitivity in ambulatory surgical patients: a correlation of historical factors with positive serum immunoglobin E levels. Anesth Analg. 1997;85(1):44-49.

De Queiroz M, Combet S, Bérard J. Latex allergy in children: modalities and prevention. Paediatr Anaesth. 2009;19(4):313-319.

Czuppon AB, Chen Z, Rennert S. The rubber elongation factor of rubber trees (Hevea brasiliensis) is the major allergen in latex. J Allergy Clin Immunol. 1993;92(5):690-697.

Peixinho C, Tavares P, Tomáz MR. Differential expression of allergens on the internal and external surfaces of latex surgical gloves. Allergol Immunopathol. 2006;34(5):206-211.

Slater JE, Chhabra SK. Latex antigens. J Allergy Clin Immunol. 1992;89(3):673-678.

Tomazic-Jezic VJ, Sanchez BA. Allergen profiles of natural rubber latex (NRL) proteins on gloves and glove powders. J Long Term Eff Med Implants. 2005;15(2):115-124.

Baur X, Chen Z, Allmers H. Can a threshold limit value for natural rubber latex airborne allergens be defined?. J Allergy Clin Immunol. 1998;101(1):24-27.

Konrad C, Fieber T, Gerber H. The prevalence of latex sensitivity among anesthesiology staff. Anesth Analg. 1997;84(3):629-633.

Hochleitner BW, Menardi G, Haussler B. Spina bifida as an independent risk factor for sensitization to latex. J Urol. 2001;166(6):2370-2373.

Nieto A, Mazon A, Pamies R. Efficacy of latex avoidance for primary prevention of latex sensitization in children with spina bifida. J Pediatr. 2002;140(3):370-372.

Machado M, Santanna C, Aires V. Latex and banana allergies in children with myelomeningocele in the city of Rio de Janeiro. Rev Assoc Med Bras. 2004;50(1):83-86.

Martinez-Lage JF, Molto MA, Pagan JA. Latex allergy in patients with spina bifida: prevention and treatment. Neurocirugia. 2001;12(1):36-42.

Mazon A, Nieto A, Pamies R. Influence of the type of operations on the development of latex sensitization in children with myelomeningocele. J Pediatr Surg. 2005;40(4):688-692.

Brown RH, Hamilton RG, Mintz M. Genetic predisposition to latex allergy: role of interleukin 13 and interleukin 18. Anesthesiology. 2005;102(3):496-502.

Monitto CL, Hamilton RG, Levey E. Genetic predisposition to natural rubber latex allergy differs between health care workers and high-risk patients. Anesth Analg. 2010;110(5):1310-1317.

Blanco C, Sanchez-Garcia F, Torres-Galvan MJ. Genetic basis of the latex-fruit syndrome: association with HLA class II alleles in a Spanish population. J Allergy Clin Immunol. 2004;114(5):1070-1076.

Laws P. The clinical implications of latex-fruit allergy. Anaesthesia. 2008;63(2):211-212.

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