Brazilian Journal of Anesthesiology
https://bjan-sba.org/article/doi/10.1590/S0034-70942008000500011
Brazilian Journal of Anesthesiology
Miscellaneous

O papel dos antagonistas periféricos dos opióides no tratamento da dor e nos cuidados perioperatórios

The role of peripheral opiate antagonists in pain medicine and perioperative care

Pedro Paulo Tanaka; Jonathan Moss

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Resumo

JUSTIFICATIVA E OBJETIVOS: Estudos clínicos e pré-clínicos sobre os antagonistas periféricos dos opióides aumentaram nosso conhecimento sobre os efeitos dos opióides exógenos e endógenos. CONTEÚDO: Este artigo faz uma revisão dos estudos clínicos e pré-clínicos sobre a disfunção intestinal secundária ao uso de opióides. CONCLUSÕES: Se forem aprovados, esses fármacos podem representar soluções importantes para os problemas encontrados na prática médica com relação ao tratamento da dor.

Palavras-chave

ANALGÉSICOS, Opióides, COMPLICAÇÕES

Abstract

BACKGROUND AND OBJECTIVES: Pre-clinical and clinical trials of peripheral opiate antagonists have shed new light on the effects of exogenous and endogenous opioids. CONTENTS: This article review preclinical studies and clinical opioid bowel disfunction trials. CONCLUSIONS: If approved these drugs may offer potential solutions to important clinical problems in pain management.

Keywords

ANALGESICS, Opioids, COMPLICATIONS

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