Lactato como prognóstico de mortalidade e falência orgânica em pacientes com síndrome da resposta inflamatória sistêmica

Domingos Dias Cicarelli; Joaquim Edson Vieira; Fábio Ely Martins Benseñor

doi:10.1590/S0034-70942007000600005

Scientific Article

Lactato como prognóstico de mortalidade e falência orgânica em pacientes com síndrome da resposta inflamatória sistêmica

Lactate as a predictor of mortality and multiple organ failure in patients with the systemic inflammatory response syndrome

Domingos Dias Cicarelli; Joaquim Edson Vieira; Fábio Ely Martins Benseñor

http://dx.doi.org/10.1590/S0034-70942007000600005 Braz J Anesthesiol, vol.57, n6, p.630-638, 2007

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Resumo

JUSTIFICATIVA E OBJETIVOS: A síndrome da resposta inflamatória sistêmica (SRIS) é comum em pacientes em estado crítico no pós-operatório. O objetivo deste estudo foi investigar a correlação entre dosagem de lactato, disfunção de múltiplos órgãos e mortalidade em pacientes com diagnóstico de SRIS. MÉTODO: Estudo prospectivo que avaliou 24 pacientes com diagnóstico de SRIS (Colégio Americano de Cirurgiões Torácicos/Sociedade Americana de Medicina Intensiva) no pós-operatório em UTI cirúrgica. O lactato foi dosado nas primeiras 24 horas após o diagnóstico de SRIS e diariamente durante 7 dias. Os pacientes foram divididos em dois grupos: Grupo LE (lactato > 2 mmol.L-1) e Grupo LN (lactato < 2 mmol.L-1). A falência de múltiplos órgãos foi avaliada pelo escore SOFA (Sequential Organ Failure Assessment) diariamente por sete dias. Após o seguimento por sete dias, os pacientes foram acompanhados até sua alta hospitalar ou óbito em 28 dias. RESULTADOS: Treze pacientes foram incluídos no Grupo LE após o diagnóstico de SRIS e 11 pacientes no Grupo LN. O risco relativo (RR) de óbito em sete dias para o Grupo LE foi 4,23 (IC 95% 2,25-7,95) vezes maior que o Grupo LN, no primeiro dia do estudo. O RR de óbito em 28 dias foi 1,7 vezes maior para o Grupo LE (IC 95% 0,84-3,46). Os grupos foram similares com relação ao SOFA durante o estudo. CONCLUSÕES: Os pacientes com lactato elevado nas primeiras 24 horas após o diagnóstico de SRIS não apresentaram mais disfunção orgânica do que os pacientes com lactato normal, porém tiveram risco aumentado de óbito em sete dias.

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MEDICINA INTENSIVA, METABOLISMO

Abstract

BACKGROUND AND OBJECTIVES: The systemic inflammatory response syndrome (SIRS) is common in the postoperative period of critically ill patients. The objective of this study was to investigate the correlation between lactate level, multiple organ dysfunction, and mortality in patients with SIRS. METHODS: This prospective study evaluated 24 patients with a postoperative diagnosis of SIRS (American College of Chest Physicians/Society of Critical Care Medicine) in the surgical ICU. Lactate levels were determined in the first 24 hours after the diagnosis of SIRS and daily, for 7 days. Patients were divided in 2 groups: LE Group (lactate > 2 mmol.L-1) and LN Group (lactate < 2 mmol.L-1). Multiple organ failure was evaluated by the SOFA (Sequential Organ Failure Assessment) score daily, for 7 days. After the 7-day follow-up period patients were followed for up to 28 days, until discharge from the hospital or death. RESULTS: Thirteen patients were included in the LE Group after the diagnosis of SIRS and 11 patients in the LN Group. The relative risk (RR) of death in 7 days for the LE Group was 4.23 (CI 95% 2.25-7.95) times greater than in the LN Group in the first day of the study. The RR of death in 28 days was 1.7 times greater for the LE Group (CI 95% 0.84-3.46). The SOFA score was similar in both groups. CONCLUSIONS: Patients with elevated lactate in the first 24 hours after the diagnosis of SIRS did not have more organic dysfunction than patients with normal lactate levels, but they had an increased risk of death in 7 days.

Keywords

INTENSIVE CARE MEDICINE, METABOLISM

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Lactato como prognóstico de mortalidade e falência orgânica em pacientes com síndrome da resposta inflamatória sistêmica

Lactate as a predictor of mortality and multiple organ failure in patients with the systemic inflammatory response syndrome

Domingos Dias Cicarelli; Joaquim Edson Vieira; Fábio Ely Martins Benseñor

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