Anestesia e síndrome do QT longo

Michelle Nacur Lorentz; Flávio Gouveia Camelo Ramiro

doi:10.1590/S0034-70942007000500010

Review Article

Anestesia e síndrome do QT longo

Anesthesia and the long QT syndrome

Michelle Nacur Lorentz; Flávio Gouveia Camelo Ramiro

http://dx.doi.org/10.1590/S0034-70942007000500010 Braz J Anesthesiol, vol.57, n5, p.543-548, 2007

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Resumo

JUSTIFICATIVA E OBJETIVOS: As disritmias cardíacas são fatores importantes de morbimortalidade no período perioperatório. Dentre as causas de disritmias, a síndrome do QT longo, tanto em sua forma genética como adquirida deve ser lembrada, já que muitos fármacos usados em anestesia, bem como ocorrências no período perioperatório podem prolongar o intervalo QT e precipitar disritmias cardíacas potencialmente malignas. CONTEÚDO: Revisão da síndrome do QT longo (LQTS), abordando suas causas e sua definição, assim como os mecanismos da doença. Além de citar vários fármacos implicados no prolongamento do intervalo QT, as abordagens anestésicas mais adequadas para os pacientes afetados são sugeridas. CONCLUSÃO: A síndrome do QT longo, possível causa de morbimortalidade intra e pós-operatória, pode estar relacionada com fármacos utilizados durante anestesia. Essa condição demanda conhecimento do anestesiologista a fim de evitar desfecho desfavorável do ato operatório.

Palavras-chave

DOENÇAS, Cardíaca, DROGAS

Abstract

BACKGROUND AND OBJECTIVES: Cardiac arrhythmias are important factors of perioperative morbidity and mortality. Among the causes of arrhythmias, the long QT syndrome, both in the genetic and acquired types, should be remembered since several drugs used in anesthesia, as well as in the perioperative period, can prolong the QT interval and trigger potentially malignant arrhythmias. CONTENTS: A review of the long QT syndrome (LQTS), discussing its causes and definition, as well as the mechanisms of the disease. Besides mentioning several drugs implicated in prolonging the QT interval, and the most adequate anesthetic approaches to affected patients are recommended. CONCLUSION: The long QT syndrome, possible cause of intra- and postoperative morbidity and mortality, can be related to drugs used during anesthesia. The anesthesiologist should have knowledge of this syndrome, in order to avoid an unfavorable outcome.

Keywords

DISEASES, Cardiac, DRUGS

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Anestesia e síndrome do QT longo

Anesthesia and the long QT syndrome

Michelle Nacur Lorentz; Flávio Gouveia Camelo Ramiro

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