Síndrome da infusão do propofol

Fabiano Timbó Barbosa

doi:10.1590/S0034-70942007000500009

Miscellaneous

Síndrome da infusão do propofol

Propofol infusion syndrome

Fabiano Timbó Barbosa

http://dx.doi.org/10.1590/S0034-70942007000500009 Braz J Anesthesiol, vol.57, n5, p.539-542, 2007

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Resumo

JUSTIFICATIVA E OBJETIVOS: A síndrome da infusão do propofol tem sido descrita como uma síndrome rara e quase sempre fatal que ocorre após infusão prolongada desse fármaco. Ela pode resultar em acidose metabólica grave, rabdomiólise, colapso cardiovascular e morte. O objetivo deste artigo foi mostrar aspectos relacionados com a síndrome da infusão do propofol por meio da revisão de literatura. CONTEÚDO: Estão definidas as características da síndrome da infusão do propofol quanto à fisiopatologia, características clínicas, tratamento e recomendações de dose para pacientes gravemente enfermos. CONCLUSÕES: O propofol deve ser usado com cautela quando se planeja seu uso sob regime de infusão contínua por períodos prolongados. O surgimento de sinais sugestivos da síndrome da infusão do propofol indica a suspensão imediata do fármaco e início de medidas de suporte.

Palavras-chave

ANESTÉSICO, Venoso, propofol, COMPLICAÇÕES

Abstract

BACKGROUND AND OBJECTIVES: Propofol infusion syndrome has been described as a rare, and frequently fatal, syndrome that occurs after prolonged infusion of this drug. It might result in severe metabolic acidosis, rhabdomyolysis, cardiovascular failure, and death. The objective of this report was to review the literature to present aspects related to the propofol infusion syndrome. CONTENTS: The physiopathology, clinical characteristics, and treatment, of the propofol infusion syndrome as well as dose recommendations for severely ill patients are presented here. CONCLUSIONS: Propofol should be used with caution when it is administered as continuous infusion for prolonged periods of time. The development of signs suggestive of the propofol infusion syndrome indicates the drug should be discontinued immediately and support measures instituted.

Keywords

ANESTHETICS, Intravenous, propofol, COMPLICATIONS

References

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Síndrome da infusão do propofol

Propofol infusion syndrome

Fabiano Timbó Barbosa

Resumo

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Abstract

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