Brazilian Journal of Anesthesiology
https://bjan-sba.org/article/doi/10.1590/S0034-70942002000100010
Brazilian Journal of Anesthesiology
Miscellaneous

Efeitos genotóxicos em profissionais expostos aos anestésicos inalatórios

Genotoxic effects on professionals exposed to inhalational anesthetics

Ana Regina Chinelato; Nívea Dulce Tedeschi Conforti Froes

http://dx.doi.org/10.1590/S0034-70942002000100010 Braz J Anesthesiol, vol.52, n1, p.79-85, 2002
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Resumo

JUSTIFICATIVA E OBJETIVOS: Neste estudo compararam-se médicos expostos aos gases anestésicos com indivíduos não expostos, para a investigação de alterações cromossômicas, verificação da possível interferência dos anestésicos inalatórios na cinética celular e avaliação do risco genotóxico associado à exposição ocupacional. MÉTODO: Foram realizadas culturas temporárias de linfócitos do sangue periférico para a obtenção de metáfases, necessárias para a análise de aberrações cromossômicas e trocas entre cromátides irmãs. RESULTADOS: A análise citogenética mostrou um aumento nas freqüências de aberrações cromossômicas por célula no grupo exposto, quando comparado ao grupo controle, denotando o efeito clastogênico desses compostos. Com relação ao parâmetro de trocas entre cromátides irmãs, os gases anestésicos não demonstraram efeito indutor. A comparação entre os índices mitótico e de proliferação celular também mostrou que não há diferenças significativas entre os grupos exposto e controle. CONCLUSÕES: Os resultados obtidos sugerem que os anestesiologistas podem representar um grupo de risco entre pessoas ocupacionalmente expostas e as condições de trabalho devem ser melhoradas.

Palavras-chave

ANESTÉSICOS, Inalatórios, RISCO PROFISSIONAL

Abstract

BACKGROUND AND OBJECTIVES: This study compared physicians exposed to anesthetics to non-exposed individuals, aiming at investigating chromosomal changes, the possible interference of inhalational anesthetics on cell kinetics and the genotoxic risk associated to occupational exposure. METHODS: Peripheral blood lymphocytes were temporarily cultured to obtain metaphases needed for the analysis of chromosomal aberrations and sister chromatid exchanges. RESULTS: Cytogenetic analysis has shown an increased frequency in chromosomal aberrations per cell in the exposed group as compared to controls, confirming the clastogenic effect of such compounds. Anesthetic gases, however, had no inducing effects on sister chromatid exchanges. The comparison between proliferation and mitotic indices has also shown no significant differences between exposed and control groups. CONCLUSIONS: Our data suggest that anesthesiologists may represent a group at risk among exposed people, and that working conditions should be improved.

Keywords

ANESTHETICS, Inhalational, PROFESSIONAL RISK

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