Brazilian Journal of Anesthesiology
https://bjan-sba.org/article/doi/10.1590/S0034-70942001000600008
Brazilian Journal of Anesthesiology
Miscellaneous

Fenoldopam: novo antihipertensivo parenteral; alternativa ao nitroprussiato

Fenoldopan: a new parenteral anti-hypertensive; an alternative to nitroprusside

Daniel Sousa César; Erika Miyoshi; Hélio Halpern; José Otávio Costa Auler Junior

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Resumo

JUSTIFICATIVA E OBJETIVOS: O fenoldopam é um agonista dopaminérgico seletivo para os receptores dopaminérgicos tipo 1 (DA-1) que causa vasodilatação periférica e o objetivo deste artigo é reunir as informações clínicas sobre este fármaco. CONTEÚDO: Neste artigo foram revisadas as experiências em urgências e emergências hipertensivas, mostrando que o fenoldopam apresenta vantagens sobre o nitroprussiato de sódio (NPS) no tratamento das mesmas. Ao contrário do NPS, o fenoldopam causa vasodilatação periférica, ao mesmo tempo que induz diurese e natriurese em pacientes com hipertensão grave sem causar os efeitos deletérios pelo tiocianato. CONCLUSÕES: O fenoldopam parenteral, pelos seus efeitos renais e menor impacto de efeitos colaterais, pode ser considerado uma boa alternativa ao nitroprussiato de sódio no tratamento de emergências hipertensivas.

Palavras-chave

ANTIHIPERTENSIVO

Abstract

Background and Objectives: Fenoldopan is a selective dopaminergic agonist for dopaminergic receptors type 1 (DA-1), which induces peripheral vasodilation. This review aimed at collecting clinical information about this drug. Contents: This study reviewed experiences in hypertensive urgencies and emergencies and has shown the advantages of fenoldopan as compared to sodium nitroprusside. As opposed to sodium nitroprusside, fenoldopan induces peripheral vasodilation at the same time that induces diuresis and natriuresis in severely hypertensive patients without the harmful effects of thiocyanate. Conclusions: Parenteral fenoldopan, for its renal effects and less adverse effects, is an interesting alternative to sodium nitroprusside in treating hypertensive emergencies.

Keywords

ANTI-HYPERTENSIVE

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