Brazilian Journal of Anesthesiology
https://bjan-sba.org/article/doi/10.1590/S0034-70942001000500005
Brazilian Journal of Anesthesiology
Scientific Article

Eficácia do ondansetron e da alizaprida na prevenção de náusea e vômito em laparoscopia ginecológica

Efficacy of ondansetron and alizapride in preventing gynecological laparoscopy nausea and vomiting

Eliana M Ganem; Paula Fabris; Marlene Z Moro; Yara Marcondes Machado Castiglia

http://dx.doi.org/10.1590/S0034-70942001000500005 Braz J Anesthesiol, vol.51, n5, p.401-406, 2001
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Resumo

JUSTIFICATIVA E OBJETIVOS: A laparoscopia ginecológica é procedimento que determina alta incidência de náusea e vômito no pós-operatório. Este estudo teve por finalidade comparar a eficácia do ondansetron e da alizaprida na prevenção de náusea e vômito em pacientes submetidas à laparoscopia ginecológica. MÉTODO: Participaram do estudo 52 pacientes, estado físico ASA I ou II, com idades entre 21 e 50 anos, sem queixas gástricas prévias, submetidas à laparoscopia para diagnóstico ou cirurgia. As pacientes foram divididas em 2 grupos: o grupo 1 recebeu ondansetron (4 mg) e o grupo 2, alizaprida (50 mg), por via venosa, antes da indução da anestesia. Todas as pacientes receberam midazolam (7,5 mg) por via oral como medicação pré-anestésica, sufentanil (0,5 µg.kg-1) e propofol (2 mg.kg-1) para indução, propofol (115 µg.kg-1) e N2O/O2 em fração inspirada de O2 a 40% para manutenção e atracúrio (0,5 mg.kg-1) como bloqueador neuromuscular. A analgesia pós-operatória foi realizada com cetoprofeno (100 mg) e buscopam composto®. RESULTADOS: Ambos os grupos foram idênticos quanto aos dados antropométricos e à duração da cirurgia e da anestesia. No grupo 1 (n=27) uma paciente apresentou náusea, No grupo 2, uma paciente apresentou náusea e três vomitaram, resultados estatisticamente não significativos. CONCLUSÕES: O ondansetron e a alizaprida foram similares na prevenção de náusea e vômito em pacientes submetidas à laparoscopia ginecológica.

Palavras-chave

ANTIEMÉTICOS, ANTIEMÉTICOS, CIRURGIA, Ginecológica, COMPLICAÇÕES, COMPLICAÇÕES

Abstract

BACKGROUND AND OBJECTIVES: Gynecological laparoscopy is a procedure with a high incidence of postoperative nausea and vomiting (PONV). This study aimed at comparing the efficacy of ondansetron and alizapride in preventing PONV in patients submitted to gynecological laparoscopy. METHODS: Participated in this study 52 women physical status ASA I and II, aged 21 to 50 years, without previous gastric complaint, who were submitted to diagnostic or surgical laparoscopy. Patients were distributed in 2 groups: Group 1 - intravenous ondansetron (4 mg) and Group 2 - intravenous alizapride (50 mg), before anesthetic induction. All patients were premedicated with oral midazolam (7.5 mg), were induced with sufentanil (0,5 µg.kg-1) and propofol (2 mg.kg-1). Propofol (115 µg.kg-1) and N2O/O2 (F I O2 = 40%) were used for maintenance, and atracurium (0,5 mg.kg-1) was the neuromuscular blocker. Postoperative analgesia was achieved with cetoprofen (100 mg) and buscopam composto®. RESULTS: Both groups were identical in demographics and surgery and anesthesia duration. One Group 1 patient referred nausea. One Group 2 patients referred nausea and 3 referred vomiting, but results were not statistically significant. CONCLUSIONS: Ondansetron and alizapride were comparable in preventing PONV in patients submitted to gynecological laparoscopy.

Keywords

ANTIEMETICS, ANTIEMETICS, COMPLICATIONS, COMPLICATIONS, SURGERY, Gynecological

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