Preoperative anemia as a marker of postoperative outcomes: a retrospective cohort study
Liege Caroline Immich, Liliane Ghi Mei Law, Igor Heineck Ouriques, Yan Prates Pimentel, Christian Camatti Menegon, Florentino Fernandes Mendes
Abstract
Background
Preoperative anemia is common and associated with adverse postoperative outcomes.
Objective
To evaluate the association between preoperative anemia severity and clinical outcomes in patients undergoing elective noncardiac surgery.
Methods
This retrospective cohort included 23,579 adults assessed preoperatively between January 2015 and August 2025, all with documented hemoglobin (Hb) and hospitalized for non-cardiac surgery. Patients were stratified as no anemia (≥ 13 g.dL⁻¹), mild (11.1‒12.9 g.dL⁻¹), moderate (8.1‒11.0 g.dL⁻¹), or severe anemia (≤ 8.0 g.dL⁻¹). Outcomes were in-hospital mortality, Intensive Care Unit (ICU) admission, and Length of Stay (LOS). Analyses used Poisson regression with robust variance adjusted for confounders.
Results
Among the participants, 15,909 (67.5%) had no anemia, 6,396 (27.1%) mild, 1,174 (5.0%) moderate, and 100 (0.4%) severe anemia. Overall, 62.6% were female, and the mean age was 60.7 years (SD ±15.4). Compared with no anemia, all anemia categories were independently associated with higher in-hospital mortality, increased ICU admission, and longer LOS. Severe anemia was the strongest predictor of in-hospital mortality (adjusted RR = 24.7; 95% CI 13.3‒46.0; p < 0.001). Intermediate or major surgeries (RR = 4.7; 95% CI 3.4‒6.6), age > 54 years (RR = 4.4; 95% CI 2.6‒7.6), and male sex (RR = 2.1; 95% CI 1.6‒2.9) were also independent predictors of in-hospital mortality.
Conclusions
Preoperative anemia, even when mild, was independently associated with higher in-hospital mortality, greater ICU admission, and prolonged hospitalization. These results support systematic screening and targeted management, including Patient Blood Management (PBM) strategies, to improve perioperative outcomes.
Keywords
References
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Submitted date:
10/25/2025
Accepted date:
03/19/2026
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