Serum lactate in anhepatic patients and the impact of continuous renal replacement therapy on its clearance: a case series
Rodolpho Augusto de Moura Pedro, Paula Sepulveda Mesquita, Frederico Almeida Baptista de Oliveira Filho, Bruna Carla Scharanch, Luís Augusto Carneiro D'Albuquerque, Luís Marcelo Sá Malbouisson
Abstract
Dear Editor,
Serum lactate is a well-recognized marker of hypoperfusion as its production increases during the anaerobic metabolism of tissue hypoxia. However, elevated lactate levels can also occur under non-hypoxic conditions due to accelerated glycolysis (e.g., in hyperthyroidism, hyper catabolism, adrenaline, salbutamol), congenital disorders, thiamine deficiency, alkalemia, lactate infusion, or under impaired liver metabolism.
References
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Submitted date:
11/08/2023
Accepted date:
07/11/2024
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