Brazilian Journal of Anesthesiology
Brazilian Journal of Anesthesiology
Original investigation

Chronic pain after hospital discharge on patients hospitalized for COVID-19: an observational study

Guilherme Antonio Moreira de Barros, Douglas Inomata Cardoso da Silva, Mariana Lopes Amaral Barbosa, Rafael Abbud Soares, Rodrigo Leal Alves, Claudio Lucas Miranda, Paula Danieli Lopes da Costa, Paulo do Nascimento Júnior, Norma Sueli Pinheiro Módolo

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There are few studies related to Coronavirus Disease 2019 (COVID-19) on the prevalence and nature of pain symptoms after hospital discharge, especially in individuals who develop moderate to severe disease forms. Therefore, this study aimed to evaluate the presence of chronic pain in patients discharged after hospitalization for COVID-19, and the relationship between the presence of chronic pain and intensive care stay, demographics, and risk factors for the worst Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outcome.


A cross-sectional observational study was carried out on patients with COVID-19 who recovered after hospitalization. Patients were recruited at the least 3 months after discharge and their hospital's health files were prospected. The variables evaluated were demographics, the severity of SARS-CoV-2 infection (considering the need for intensive care), and the presence of chronic pain. The results were shown in a descriptive manner, and multivariate analysis expressed as Odds Ratios (ORs) and respective Confidence Intervals (CIs) for the outcomes studied. Statistical significance was set at p < 0.05.


Of 242 individuals included, 77 (31.8%) reported chronic pain related to COVID-19, with no correlation with the severity of infection. Female sex and obesity were associated with a higher risk for chronic pain with ORs of 2.69 (Confidence Interval [95% CI 1.4 to 5.0]) and 3.02 (95% CI 1.5 to 5.9). The limbs were the most affected areas of the body.


Chronic pain is common among COVID-19 survivors treated in hospital environments. Female sex and obesity are risk factors for its occurrence.


Chronic pain; COVID-19; Post-COVID syndrome; Post-intensive care syndrome; SARS-CoV-2; Survivors
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Braz J Anesthesiol

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