Brazilian Journal of Anesthesiology
Brazilian Journal of Anesthesiology

Is dexmedetomidine a lazy drug or do we have lazy anesthesiologists?

Maryam Alshemeili, Francisco A. Lobo

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1 V Nguyen, D Tiemann, E Park, A. Salehi Alpha-2 Agonists Anesthesiol Clin, 35 (2017), pp. 233-245

2 LE Nelson, J Lu, T Guo, CB Saper, et al. The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects Anesthesiology, 98 (2003), pp. 428-436

3 EN Brown, KJ Pavone, M. Naranjo Multimodal general anesthesia: theory and practice Anesth Analg, 127 (2018), pp. 1246-1258

4 R Li, F Qi, J Zhang, Y Ji, et al. Antinociceptive effects of dexmedetomidine via spinal substance P and CGRP Transl Neurosci, 6 (2015), pp. 259-264

5 JP Belleville, DS Ward, BC Bloor, M. Maze Effects of intravenous dexmedetomidine in humans. I. Sedation, ventilation, and metabolic rate Anesthesiology, 77 (1992), pp. 1125-1133

6 Å Lodenius, KJ Maddison, BK Lawther, et al. Upper Airway Collapsibility during Dexmedetomidine and Propofol Sedation in Healthy Volunteers: A Nonblinded Randomized Crossover Study Anesthesiology, 131 (2019), pp. 962-973

7 Y Hu, H Zhou, H Zhang, Y Sui, et al. The neuroprotective effect of dexmedetomidine and its mechanism Front Pharmacol, 13 (2022), Article 965661

8 K Lewis, F Alshamsi, KL Carayannopoulos, A Granholm, et al. Dexmedetomidine vs other sedatives in critically ill mechanically ventilated adults: a systematic review and meta- analysis of randomized trials Intensive Care Med, 48 (2022), pp. 811-840

9 JCK Sin, A Tabah, MJJ Campher, KB Laupland, et al. The effect of dexmedetomidine on postanesthesia care unit discharge and recovery: a systematic review and meta-analysis Anesth Analg, 134 (2022), pp. 1229-1244

10 MAS Weerink, MMRF Struys, LN Hannivoort, et al. Clinical pharmacokinetics and pharmacodynamics of dexmedetomidine Clin Pharmacokinet, 56 (2017), pp. 893-913

11 PA Välitalo, T Ahtola-Sätilä, A Wighton, et al. Population pharmacokinetics of dexmedetomidine in critically ill patients Clin Drug Investig, 33 (2013), pp. 579-587

12 LN Hannivoort, DJ Eleveld, JH Proost, et al. Development of an optimized pharmacokinetic model of dexmedetomidine using target-controlled infusion in healthy volunteers Anesthesiology, 123 (2015), pp. 357-367

13 PJ Colin, LN Hannivoort, DJ Eleveld, et al. Dexmedetomidine pharmacokinetic-pharmacodynamic modelling in healthy volunteers: 1. Influence of arousal on bispectral index and sedation Br J Anaesth, 119 (2017), pp. 200-210

14 PJ Colin, LN Hannivoort, DJ Eleveld, et al. Dexmedetomidine pharmacodynamics in healthy volunteers: 2. Haemodynamic profile Br J Anaesth, 119 (2017), pp. 211-220

15 R Alvarez-Jimenez, MAS Weerink, LN Hannivoort, et al. Dexmedetomidine clearance decreases with increasing drug exposure: implications for current dosing regimens and target-controlled infusion models assuming linear pharmacokinetics Anesthesiology, 136 (2022), pp. 279-292

16 AM Youn, YK Ko, YH. Kim Anesthesia and sedation outside of the operating room Korean J Anesthesiol, 68 (2015), pp. 323-331

17 FJ Fonseca, L Ferreira, AL Rouxinol-Dias, J. Mourão Effects of dexmedetomidine in non-operating room anesthesia in adults: a systematic review with meta-analysis Braz J Anesthesiol (2021), 10.1016/j.bjane.2021.12.002 Online ahead of print

18 Y Fujita, K Inoue, T Sakamoto, S Yoshizawa, et al. A comparison between dosages and plasma concentrations of dexmedetomidine in clinically ill patients: a prospective, observational, cohort study in Japan J Intensive Care, 1 (2013), p. 15

19 TW Schnider, CF Minto, MM Struys, AR. Absalom The safety of target- controlled infusions Anesth Analg, 122 (2016), pp. 79-85

20 L Barvais, FA Lobo, FH Engbers, MG Irwin, et al. Tips and tricks to optimize total intravenous anesthesia Acta Anaesthesiol Belg, 64 (2013), pp. 137-146

21 FA Lobo, A. Shander Modern Anesthetic Noninvasive Monitoring: A Deep Look into Perioperative Care J Cardiothorac Vasc Anesth, 33 (Suppl 1) (2019), pp. S1-S2

22 J Montupil, A Defresne, V. Bonhomme The raw and processed electroencephalogram as a monitoring and diagnostic tool J Cardiothorac Vasc Anesth, 33 (Suppl 1) (2019), pp. S3-S10

23 PL Purdon, A Sampson, KJ Pavone, EN. Brown Clinical electroencephalography for anesthesiologists: Part I: background and basic signatures Anesthesiology, 123 (2015), pp. 937-960

24 FA Lobo, S. Schraag Limitations of anaesthesia depth monitoring Curr Opin Anaesthesiol, 24 (2011), pp. 657-664

25 Z Moaiyeri, F Duarte, M Lamperti, FA. Lobo Peri-operative multimodal monitoring: a real need or a luxury? J Clin Monit Comput (2022), 10.1007/s10877-022-00914-1 Online ahead of print

26 D Li, MS Fabus, JW. Sleigh Brain Complexities and Anesthesia: Their Meaning and Measurement Anesthesiology, 137 (2022), pp. 290-302

27 S. Staender Safety-II and resilience: the way ahead in patient safety in anaesthesiology Curr Opin Anaesthesiol, 28 (2015), pp. 735-739

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