Brazilian Journal of Anesthesiology
Brazilian Journal of Anesthesiology
Systematic Review

Prone ventilation in intubated COVID-19 patients: a systematic review and meta-analysis

Ventilação prona em pacientes intubados com COVID-19: uma revisão sistemática e meta-análise

Ee Xin Chua, Zhen Zhe Wong, Mohd Shahnaz Hasan, Rafidah Atan, Nor'azim Mohd Yunos, Hing Wa Yip, Wan Yi Teoh, Mohd Afiq Syahmi Ramli, Ka Ting Ng

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The efficacy and safety profiles of prone ventilation among intubated Coronavirus Disease 2019 (COVID-19) patients remain unclear. The primary objective was to examine the effect of prone ventilation on the ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO2) in intubated COVID-19 patients.

Databases of MEDLINE, EMBASE and CENTRAL were systematically searched from inception until March 2021. Case reports and case series were excluded.

Eleven studies (n = 606 patients) were eligible. Prone ventilation significantly improved PaO2/FiO2 ratio (studies: 8, n = 579, mean difference 46.75, 95% CI 33.35‒60.15, p < 0.00001; evidence: very low) and peripheral oxygen saturation (SpO2) (studies: 3, n = 432, mean difference 1.67, 95% CI 1.08‒2.26, p < 0.00001; evidence: ow), but not the arterial partial pressure of carbon dioxide (PaCO2) (studies: 5, n = 396, mean difference 2.45, 95% CI 2.39‒7.30, p = 0.32; evidence: very low), mortality rate (studies: 1, n = 215, Odds Ratio 0.66, 95% CI 0.32‒1.33, p = 0.24; evidence: very low), or number of patients discharged alive (studies: 1, n = 43, Odds Ratio 1.49, 95% CI 0.72‒3.08, p = 0.28; evidence: very low).

Prone ventilation improved PaO2/FiO2 ratio and SpO2 in intubated COVID-19 patients. Given the substantial heterogeneity and low level of evidence, more randomized- controlled trials are warranted to improve the certainty of evidence, and to examine the adverse events of prone ventilation.


Acute respiratory distress syndrome;  COVID-19;  Intubation;  Prone position;  Supine position;  Ventilation


Justificativa: Os perfis de eficácia e segurança da ventilação prona entre pacientes intubados com doença de coronavírus 2019 (COVID-19) permanecem obscuros. O objetivo primário foi examinar o efeito da ventilação prona na razão da pressão parcial arterial de oxigênio para a fração inspirada de oxigênio (PaO2 /FiO2 ) em pacientes intubados com COVID-19. Métodos: As bases de dados MEDLINE, EMBASE e CENTRAL foram sistematicamente pesquisadas desde o início até março de 2021. Relatos de casos e séries de casos foram excluídos. Resultados: Onze estudos (n = 606 pacientes) foram elegíveis. A ventilação prona melhorou significativamente a relação PaO2 /FiO2 (estudos: 8, n = 579, diferença média 46,75, IC 95% 33,35-60,15, p < 0,00001; evidência: muito baixa) e saturação periférica de oxigênio (SpO2 ) (estudos: 3, n = 432, diferença média 1,67, IC 95% 1,08-2,26, p < 0,00001; evidência: baixa), mas não a pressão parcial arterial de dióxido de carbono (PaCO2 ) (estudos: 5, n = 396, diferença média 2,45, 95% CI-2,39-7,30, p = 0,32; evidência: muito baixa), taxa de mortalidade (estudos: 1, n = 215, odds ratio 0,66, IC 95% 0,32-1,33, p = 0,24; evidência: muito baixa) ou número de pacientes que receberam alta vivos (estudos: 1, n = 43, odds ratio 1,49, IC 95% 0,72-3,08, p = 0,28; evidência: muito baixa). Conclusão: A ventilação prona melhorou a relação PaO2 /FiO2 e SpO2 em pacientes intubados com COVID-19. Dada a heterogeneidade substancial e o baixo nível de evidência, mais estudos randomizados controlados são necessários para melhorar a certeza das evidências e para examinar os eventos adversos da ventilação em posição prona.


Síndrome da insuficiência respiratória aguda; COVID-19; Intubação; Posição prona; Posição supina; Ventilação


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