Brazilian Journal of Anesthesiology
https://bjan-sba.org/article/doi/10.1016/j.bjane.2021.07.034
Brazilian Journal of Anesthesiology
Case Report

Sugammadex administration in pregnant patients undergoing non-obstetric surgery: a case series

Administração de sugamadex em gestantes submetidas à cirurgia não obstétrica: uma série de casos

Sara Martins Torres; Duarte Filipe Duarte; Amélia Sousa Glória; Cláudia Reis; Joana Filipa Moreira; Sara Cunha; Lino Lopes Gomes; Caroline Dahlem

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Abstract

The use of sugammadex for reversal of rocuronium-induced neuromuscular blockade after caesarean section is nowadays common practice, but concerns exist about its use in pregnant women undergoing non-obstetric surgery. We report six cases of pregnant women submitted to general anesthesia for non-obstetric surgery in which neuromuscular blockade was reversed with sugammadex. We followed the outcome of both mother and baby during and after delivery. Sugammadex seemed to be a safe option for both mother and baby but more reports are necessary to fill the evidence gap and increase the global knowledge about its safety in this special group of patients.

Keywords

Sugammadex;  Neuromuscular blockade;  Pregnancy;  Non-obstetric surgery;  Fetal development

Resumo

O uso de sugamadex para reversão do bloqueio neuromuscular induzido por rocurônio após cesariana é prática comum atualmente, mas existem preocupações quanto ao seu uso em gestantes submetidas a cirurgias não obstétricas. Relatamos seis casos de gestantes submetidas à anestesia geral para cirurgia não obstétrica em que o bloqueio neuromuscular foi revertido com sugamadex. Acompanhamos o resultado da mãe e do bebê durante e após o parto. Sugamadex parecia ser uma opção segura tanto para a mãe quanto para o bebê, mas são necessários mais relatórios para preencher a lacuna de evidências e aumentar o conhecimento global sobre sua segurança neste grupo especial de pacientes.

Palavras-chave

Sugamadex; Bloqueio neuromuscular; Gravidez; Cirurgia não obstétrica; Desenvolvimento fetal

References

1 J.C.G. Martínez, O. Sequera, G. Guánchez Pheochromocytoma in pregnancy: a case report J Anesth Crit Care Open Access., 7 (2017), Article 00266

2 V. Singh, P. Bhakta, J. Hashmi, et al. Cardioversion in late pregnancy: a case report Acta Anaesthesiol Belg., 65 (2014), pp. 105-107

3 A. Munro, D. McKeen, J. Coolen Maternal respiratory distress and successful reversal with sugammadex during intrauterine transfusion with fetal paralysis Int J Obstet Anesth., 39 (2019), pp. 129-131

4 A.M. Hristovska, P. Duch, M. Allingstrup, et al. Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults Cochrane Database Syst Rev., 8 (2017), Article CD012763

5 Society for Obstetric Anesthesia and Perinatology Statement on Sugammadex during pregnancy and lactation [cited 2019 July 31]. Available from: https://soap.org/wp-content/uploads/2019/06/SOAP_Statement_Sugammadex_During_Pregnancy_Lactation_APPROVED.pdf (2019)

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