Brazilian Journal of Anesthesiology
https://bjan-sba.org/article/doi/10.1016/j.bjane.2021.07.033
Brazilian Journal of Anesthesiology
Experimental Trials

The effects of dexketoprofen on renal ischemia-reperfusion injury: an experimental study

Ersin Koksal; Yasemin Burcu Ustun; Sezgin Bilgin; Abdurrahman Aksoy; Yavuz Kürşad Daş; Murat Yarim; Fatih Özkan; Cengiz Kaya; Burhan Dost

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Abstract

Objective
Ischemia/reperfusion (I/R) may cause irreversible damage to tissues and organs. We evaluated the effects of dexketoprofen on a renal I/R model in rats.

Methods
The study included 30 male rats. Control group received 1 mL of saline. Dexketoprofen group received 1 mL (25 mg) of dexketoprofen intraperitoneally. After 60 minutes renal ischemia, 23 hours reperfusion was applied. In Sham group, laparotomy was performed with a medial line incision without any additional procedure. Changes in the plasma malondialdehyde (MDA), renal tissue MDA, plasma glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), BUN, creatinine and albumin levels, and histopathological changes were evaluated.

Results
CAT values were significantly lower in Control as compared with the Sham group. Plasma levels of MDA in the Control group were significantly higher than in the Dexketoprofen group. BUN and creatinine values were significantly higher in the Dexketoprofen group. The severity of tissue injury in the Dexketoprofen group was significantly higher than in Control and Sham groups

Conclusion
Although dexketoprofen reduces the I/R-induced systemic inflammation, it increases renal tissue damage.

Keywords

Dexketoprofen;  Ischemia- reperfusion;  Kidney;  Malondialdehyde;  Reactive oxygen species

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