General anesthesia for old Werner syndrome patient: a case report
Werner syndrome (WS) is a rare autosomal recessive, premature aging disorder whose clinical manifestations include short stature, bilateral cataracts, diabetes mellitus, hypertension, and atherosclerosis. WS first manifests during adolescence and patients usually die at 40–50 years of age. Only symptomatic treatment options available according to clinical manifestations. In anesthetic management, they need to be considered to elderly patients. Difficult intubation is expected and the patients are regarded as a high-risk group for anesthesia, owing to the concomitant cardiovascular and cerebrovascular disorders. The anesthetic management of WS requires a meticulous preoperative history taking, physical examination, and preparation for cardiovascular events.
1 M. Goto Hierarchical deterioration of body systems in Werner’s syndrome: implications for normal ageing Mech Ageing Dev., 98 (1997), pp. 239-254
2 M. Takemoto, S. Mori, M. Kuzuya, et al. Diagnostic criteria for Werner syndrome based on Japanese nationwide epidemiological survey Geriatr Gerontol Int., 13 (2013), pp. 475-481
3 K. Yokote, Y. Saito Extension of the life span in patients with Werner syndrome J Am Geriatr Soc., 56 (2008), pp. 1770-1771
4 L Aurini, PF White Anesthesia for the elderly outpatient Curr Opin Anaesthesiol., 27 (2014), pp. 563-575