Quadratus lumborum block (QLB) is a technique that is not widely applied for gynaecological surgery. Endometriosis affects 10% of the female population and chronic pelvic pain is one of the most prevalent symptoms. Laparoscopic surgery for removal of endometriosis may present a long intra-operative duration and this technique might improve postoperative pain control. We described a case report of a patient submitted to general anaesthesia associated to bilateral QLB for pelvic endometriosis. QLB was an adjuvant anaesthetic technique for endometriosis, providing somatic and visceral analgesia. However, prospective studies are needed to identify the standard dosage and total duration of analgesia.