Brazilian Journal of Anesthesiology
https://bjan-sba.org/article/doi/10.1016/j.bjane.2020.12.016
Brazilian Journal of Anesthesiology
Case Report

Effects of allopurinol on pain and anxiety in fibromyalgia patients: a pilot study

Efeitos do alopurinol na dor e na ansiedade em pacientes com infibromialgia: um estudo piloto

Aécio C. Fagundes, Diogo O. Souza, André P. Schmidt

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Abstract

Allopurinol is a potent inhibitor of the enzyme xanthine oxidase used in the treatment of hyperuricemia and gout. The aim of this pilot study was to investigate the effects of allopurinol on pain and anxiety in women displaying fibromyalgia refractory to conventional therapy. This prospective case series enrolled 12 women with previous diagnosis of fibromyalgia refractory to conventional therapy. Patients received an add-on therapy with oral allopurinol 300 mg twice daily for 30 days. Patients were submitted to evaluation for pain and anxiety scores before treatment, 15 and 30 days thereafter. This pilot study has demonstrated that oral administration of allopurinol 300 mg twice daily caused a significant reduction on pain scores up to 30 days of treatment in women with fibromyalgia. No effect was observed regarding anxiety scores. Randomized clinical trials are warranted and should further investigate allopurinol and more selective purine derivatives in the management of acute or chronic pain conditions.

Keywords

Allopurinol;  Chronic pain;  Fibromyalgia;  Anxiety;  Purines

References

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2 J. Sawynok, X.J. Liu Adenosine in the spinal cord and periphery: release and regulation of pain Prog Neurobiol, 69 (2003), pp. 313-340

3 A.P. Schmidt, A.E. Böhmer, C. Antunes, et al. Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors Br J Pharmacol, 156 (2009), pp. 163-172

4 W. Caumo, A.P. Schmidt, C.N. Schneider, et al. Risk factors for postoperative anxiety in adults Anaesthesia, 56 (2001), pp. 720-728

5 A.P. Schmidt, D.R. Lara, D.O. Souza Proposal of a guanine-based purinergic system in the mammalian central nervous system Pharmacol Ther, 116 (2007), pp. 401-416

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