Brazilian Journal of Anesthesiology
https://bjan-sba.org/article/doi/10.1016/j.bjane.2020.07.006
Brazilian Journal of Anesthesiology
Clinical Research

Effects of music therapy on pain and oxidative stress in oocyte pick-up: A randomized clinical trial

Efeitos da musicoterapia sobre dor e estresse oxidativo na aspiração folicular: um estudo clínico randomizado

Yavuz Orak, Suleyman Murat Bakacak, Asli Yaylalı, Fatma Inanc Tolun, Hakan Kıran, Omer Faruk Boran, Akif Hakan Kurt, Adem Doganer

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Abstract

Background and objective
The aim was to investigate the effects of Turkish classical music on pain and oxidative stress in patients undergoing oocyte pick-up.

Methods
The study was a randomized, controlled trial. The groups included Group NM (Non-Music), control group; Group PM, which comprised patients who listened to music before the operation; and Group CM, which comprised patients who listened to music both before and during the operation. Blood was drawn prior to the operation to measure the oxidative stress values. Pain, hemodynamic parameters, oxidative stress values were assessed postoperatively.

Results
The number of patients requiring additional propofol was higher in Group PM than in Groups NM and CM (p = 0.003). The postoperative Visual Analog Scale (VAS) score were lower in Groups PM and CM than in Group NM (p = 0.001, p = 0.007) in the 1st and 60th minutes. The postoperative VAS score was lower in Group CM than in Group NM (p = 0.045) in the 5th minute. The postoperative additional analgesic requirements were lower in Groups PM and CM than in Group NM (p = 0.045). The postoperative blood glutathione peroxidase values were significantly higher in Groups PM and CM than in Group NM (p = 0.001). The postoperative catalase values were significantly higher in Groups PM and CM than in Group NM (p = 0.008 and p < 0.001). The preoperative malondialdehyde values were significantly lower in Groups PM and CM than in Group NM. The preoperative nitric oxide values were higher in Groups PM and CM than in Group NM (p < 0.001), whereas the postoperative nitric oxide values were lower in Groups PM and CM than in Group NM (p < 0.001).

Conclusion
Turkish classical music has beneficial effects on pain and oxidative stress in oocyte pick-up patients.

Keywords

Oocyte retrieval;  Music therapy;  Pain;  Oxidative stress

Resumo

Justificativa e objetivo
O objetivo deste estudo foi investigar os efeitos da música clássica turca sobre a dor e o estresse oxidativo em pacientes submetidas a aspiração folicular.

Método
Estudo randomizado controlado. Os grupos foram: grupo controle NM, sem música; Grupo PM, com pacientes que ouviram música antes da cirurgia; e Grupo CM, com pacientes que ouviram música antes e durante a cirurgia. Foi coletado sangue antes da cirurgia para avaliar os valores de estresse oxidativo. Dor, parâmetros hemodinâmicos e valores de estresse oxidativo foram avaliados após a cirurgia.

Resultados
O número de pacientes que necessitou de propofol adicional foi mais alto no Grupo PM do que nos Grupos NM e CM (p = 0,003). A pontuação da Escala Visual Analógica (EVA) pós-operatória foi mais baixa nos Grupos PM e CM do que no Grupo NM (p = 0,001; p = 0,007) no 1° e 60° minutos. A pontuação da EVA pós-operatória foi mais baixa no Grupo CM do que no Grupo NM (p = 0,045) no 5° minuto. A necessidade de analgesia pós-operatória adicional foi mais baixa nos Grupos PM e CM do que no Grupo NM (p = 0,045). Os valores pós-operatórios de glutationa peroxidase no sangue foram significantemente mais altos nos Grupos PM e CM do que no Grupo NM (p = 0,001). Os valores pós-operatórios de catalase foram significantemente mais altos nos Grupos PM e CM do que no Grupo NM (p = 0,008 e p < 0,001). Os valores pré-operatórios de malondialdeído foram significantemente mais baixos nos Grupos PM e CM do que no Grupo NM. Os valores pré-operatórios de óxido nítrico foram mais altos nos Grupos PM e CM do que no Grupo NM (p < 0,001), ao passo que valores pós-operatórios de óxido nítrico foram mais baixos nos Grupos PM e CM do que no grupo NM (p < 0,001).

Conclusão
Música clássica turca exerce efeito benéfico sobre a dor e estresse oxidativo em pacientes na aspiração folicular.

Palavras-chave

Aspiração folicular;  Musicoterapia;  Dor estresse oxidativo

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