1 S Okamoto, U Okamoto Amino-Methyl-Cyclohexane-Carboxylic Acid: AMCHA. A new potent inhibitor of the fibrinolysis Keio J Med., 11 (1962), pp. 105-115

2 C. Guerriero, J. Cairns, P. Perel, et al. Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial PLoS One., 6 (2011), Article e18987

3 L.S. Sudhof, A.S. Shainker, B.D. Einerson Tranexamic acid in the routine treatment of postpartum hemorrhage in the United States: A cost-effectiveness analysis Am J Obstet Gynecol., 221 (2019), p. 275

4 CRASH-2 Trial Collaborators Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomized, placebo-controlled trial Lancet., 376 (2010), pp. 23-32

5 WOMAN Trial Collaborators Effects of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial Lancet., 389 (2017), pp. 2105-2116

6 K.H. Levy, A. Koster, Q.J. Quinones, et al. Antifibrinolytic therapy and perioperative considerations Anesthesiology, 128 (2018), pp. 657-670

7 F. Huang, D. Wu, G. Ma, et al. The use of tranexamic acid to reduce blood loss and transfusion in major orthopaedic surgery: a metaanalysis J Surg Res., 186 (2014), pp. 318-327

8 M. Franchini, C. Mengoli, M. Marietta, et al. Safety of intravenous tranexamic acid in patients undergoing major orthopaedic surgery: a meta-analysis of randomized controlled trials Blood Transfus., 16 (2018), pp. 36-43

9 P. McCormack Tranexamis acid Drugs., 72 (2012), pp. 585-617

10 R. Saravanan, R. Venkatraman, K. Karthik, A. Pushparani Efficacy of different doses and timing of tranexamic acid in major orthopedic surgeries: a randomized trial Rev Bras Anestesiol. (2020), 10.1016/j.bjane.2020.06.008

11 E. Souza Neto, G. Usandizaga Comparison of two doses of intra-articular tranexamic acid on postoperative bleeding in total knee arthroplasty: a randomized clinical trial Rev Bras Anestesiol. (2020), 10.1016/j.bjane.2020.03.004