Brazilian Journal of Anesthesiology
Brazilian Journal of Anesthesiology
Scientific Article

Effectiveness of platelet rich plasma in pain management of osteoarthritis knee: Double blind, randomized comparative study

Efetividade do plasma rico em plaquetas no tratamento da dor em osteoartrite de joelho: estudo comparativo randômico e duplo‐cego

Babita Ghai, Vasudha Gupta, Ashish Jain, Nitika Goel, Devender Chouhan, Yatinder Kumar Batra

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Intra‐articular injections of platelet‐rich plasma to treat symptoms of knee osteoarthritis have been successfully used in young patients. However in most of these studies the control and test knees were present in different patients thus incorporating a large amount of bias in the results. Therefore, the present study was designed in which patients with bilateral osteoarthritis knee were included and platelet‐rich plasma was administered in one knee and normal saline in another knee of same patient.

20 patients aged 30‐65years with bilateral osteoarthritis knees (ASA class I and II) of either gender were included in the study. Patients were randomized to receive platelet‐rich plasma and normal saline in one of the two knees. The primary outcome was VAS and WOMAC score at 6 months after procedure. The secondary outcome included changes in joint stiffness, physical function, any adverse effects noted during the course of study.

The baseline VAS score in platelet‐rich plasma knee was 8.4 ± 0.88 which improved significantly to 4.85 ± 2.48 (p < 0.001) at 6 months as compared to normal saline knee (p = 0.017). The WOMAC pain score also improved from baseline (14.5 ± 1.3) to over 6 month 7.00 ± 4.24 (p < 0.001) in platelet‐rich plasma knee while in the normal saline knee, no significant change occurred from baseline to six months (10.2 ± 1.2 to 10.05 ± 1.23). There was also significant decrease in stiffness and improvement of physical activity in the platelet‐rich plasma knee as compared to normal saline knee.

The present study showed significant decrease in pain and stiffness and improvement of physical functions of knee joint with intra‐articular platelet‐rich plasma injection as compared to normal saline.


Osteoarthritis knee; Platelet rich plasma; WOMAC score


Justificativa e objetivos
Injeções intra‐articulares de plasma rico em plaquetas têm sido usadas com sucesso para tratar os sintomas da osteoartrite de joelho em pacientes jovens. Porém, na maioria desses estudos, os joelhos de controle e teste estavam presentes em diferentes pacientes, o que incorporou uma grande quantidade de viés aos resultados. Portanto, o projeto do presente estudo incluiu pacientes com osteoartrite em ambos os joelhos, com a administração de plasma rico em plaquetas em um dos joelhos e de solução salina normal no outro joelho do mesmo paciente.

20 pacientes, de ambos os sexos, com idades entre 30-65 anos e portadores de osteoartrite bilateral de joelho (classificação ASA I e II) foram incluídos no estudo. Os pacientes foram randomizados para receber plasma rico em plaquetas e solução salina normal em um dos dois joelhos. O desfecho primário foram os escores VAS e WOMAC seis meses após o procedimento. O desfecho secundário incluiu alterações na rigidez articular, função física e qualquere feito adverso observado durante o curso do estudo.

O escore VAS basal para o joelho que recebeu plasma rico em plaquetas foi 8,4 ± 0,88 e melhorou significativamente para 4,85 ± 2,48 (p < 0,001) após seis meses, comparado ao joelho que recebeu solução salina normal (p = 0,017). A intensidade da dor avaliada com o WOMAC também melhorou de 14,5 ± 1,3 na fase basal para 7,00 ± 4,24 após seis meses (p < 0,001) nos joelhos que receberam plasma rico em plaquetas, enquanto nenhuma mudança significativa ocorreu nos joelhos que receberam solução salina normal entre a fase basal e após seis meses (10,2 ± 1,2 a 10,05 ± 1,23). Além disso, houve uma diminuição significativa da rigidez e melhoria da atividade física nos joelhos que receberam plasma rico em plaquetas, comparados aos joelhos que receberam salina normal.

O presente estudo identificou uma diminuição significativa da dor e da rigidez e uma melhoria das funções físicas da articulação do joelho com a injeção intra‐articular de plasma rico em plaquetas, comparada à solução salina normal.


Osteoartrite de joelho; Plasma rico em plaquetas; Escore WOMAC


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