Brazilian Journal of Anesthesiology
https://bjan-sba.org/article/doi/10.1016/j.bjane.2014.03.011
Brazilian Journal of Anesthesiology
Scientific Article

Carotid endarterectomy: review of 10 years of practice of general and locoregional anesthesia in a tertiary care hospital in Portugal

Endarterectomia carotídea: revisão de 10 anos de prática de anestesia geral e locorregional num hospital terciário em Portugal

Mercês Lobo; Joana Mourão; Graça Afonso

Downloads: 1
Views: 822

Abstract

BACKGROUND:: Retrospective and prospective randomized studies have compared general and locoregional anesthesia for carotid endarterectomy, but without definitive results.

OBJECTIVES:: Evaluate the incidence of complications (medical, surgical, neurological, and hospital mortality) in a tertiary center in Portugal and review the literature.

METHODS:: Retrospective analysis of patients undergoing endarterectomy between 2000 and 2011, using a software for hospital consultation.

RESULTS:: A total of 750 patients were identified, and locoregional anesthesia had to be converted to general anesthesia in 13 patients. Thus, a total of 737 patients were included in this analysis: 74% underwent locoregional anesthesia and 26% underwent general anesthesia. There was no statistically significant difference between the two groups regarding per operative variables. The use of shunt was more common in patients undergoing general anesthesia, a statistically significant difference. The difference between groups of strokes and mortality was not statistically significant. The average length of stay was shorter in patients undergoing locoregional anesthesia with a statistically significant difference.

CONCLUSIONS:: We found that our data are overlaid with the literature data. After reviewing the literature, we found that the number of studies comparing locoregional and general anesthesia and its impact on delirium, cognitive impairment, and decreased quality of life after surgery is still very small and can provide important data to compare the two techniques. Thus, some questions remain open, which indicates the need for randomized studies with larger number of patients and in new centers.

Keywords

Carotid endarterectomy, General and locoregional anesthesia, Anesthesia for vascular surgery, Review

Resumo

JUSTIFICATIVA:: Estudos retrospectivos e prospectivos randomizados têm comparado a anestesia locorregional e geral para endarterectomia carotídea, mas sem resultados definitivos.

OBJETIVOS:: Avaliar a incidência de complicações (médicas, cirúrgicas, neurológicas e mortalidade intra-hospitalar) num centro terciário em Portugal e revisão da literatura.

MÉTODO:: Análise retrospectiva dos doentes submetidos a endarterectomia entre 2000 e 2011 com o software consulta hospitalar.

RESULTADOS:: Foram identificados 750 doentes, mas em 13 foi necessário converter a anestesia locorregional em anestesia geral. Dos 737 doentes incluídos nesta análise, 74% foram submetidos a anestesia locorregional e 26% a anestesia geral. Não foram encontradas diferenças estatisticamente significativas relativamente às variáveis estudadas no perioperatório entre os dois grupos. O uso de shunt foi mais frequente em doentes submetidos a anestesia geral, diferença estatisticamente significativa. A diferença entre grupos de acidentes vasculares cerebrais e mortalidade não foi estatisticamente significativa. O tempo médio de internamento foi mais curto nos doentes submetidos a anestesia locorregional, diferença estatisticamente significativa.

CONCLUSÕES:: Verificamos que os dados encontrados são sobreponíveis aos descritos na literatura. Após revisão da literatura constatamos que o número de estudos que comparam anestesia locorregional e anestesia geral e o seu impacto no delirium, nas alterações cognitivas e na diminuição da qualidade de vida no pós-operatório é ainda diminuto e pode fornecer dados importantes para a comparação das duas técnicas. Assim, permanecem algumas questões em aberto que obrigam à feitura de estudos randomizados com maior número de doentes e em novas áreas.

Palavras-chave

Endarterectomia carotídea, Anestesia geral e locorregional, Anestesia para cirurgia vascular, Revisão

References

Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. JAMA.. 1995;273:1421-8.

Methods, patient characteristics, and progress. Stroke.. 1991;22:711-20.

Halm EA, Hannan EL, Rojas M. Clinical and operative predictors of outcomes of carotid endarterectomy. Journal of Vascular Surgery.. 2005;42:420-8.

Reed A. Preoperative risk factors for carotid endarterectmoy: defining the patient at high risk. J Vasc Surg.. 2003;37:1191-9.

Kang JL, Chung TK, Lancaster RT. Outcomes after caro- tid endarterectomy: is there a high-risk population? A National Surgical Quality Improvement Program report. J Vasc Surg. 2009;49:33-18-339.e1-discussion 338-9.

Gasparis AP, Ricotta L, Cuadra SA. High-risk carotid endarterec- tomy: fact or fiction. J Vasc Surg.. 2003;37:40-6.

Gasecki AP, Eliasziw M, Ferguson GG. Long-term progno- sis and effect of endarterectomy in patients with symptomatic severe carotid stenosis and contralateral carotid stenosis or occlusion: results from NASCET. J Neurosurg.. 1995;83:778-82.

Jackson RS, Black JH III, Lum YW. Class I obesity is paradoxically associated with decreased risk of postope- rative stroke after carotid endarterectomy. YMVA [Internet].. 2012;55:1306-12.

Garg J, Frankel DA, Dilley RB. Carotid endarterectomy in aca- demic versus community hospitals: the national surgical quality improvement program data. Ann Vasc Surg.. 2011;25:433-41.

LaMuraglia GM, Brewster DC, Moncure AC. Carotid endar- terectomy at the millennium. Ann Surg.. 2004;240:535-46.

GALA Trial Collaborative Group, Lewis SC, Warlow CP. General anaesthesia versus local anaesthesia for carotid sur- gery (GALA): a multicentre, randomised controlled trial. Lancet [Internet].. 2008;372:2132-42.

Gomes M, Soares MO, Dumville JC. Co-effectiveness analy- sis of general anaesthesia versus local anaesthesia for carotid surgery (GALA Trial). Br J Surg.. 2010;97:1218-25.

Leichtle SW, Mouawad NJ, Welch K. Outcomes of carotid endarterectomy under general and regional anesthesia from the American College of Surgeons' National Surgical Quality Impro- vement Program. J Vasc Surg.. 2012;56:81.

Rerkasem K, Rothwell PM. Local versus general anesthetic for carotid endarterectomy. Stroke.. 2009;40:e584-5.

Hans SS, Jareunpoon O. Prospective evaluation of electroen- cephalography, carotid artery stump pressure, and neurologic changes during 314 consecutive carotid endarterectomies per- formed in awake patients. J Vasc Surg.. 2007;45:511-5.

Friedell ML, Clark JM, Graham DA. Cerebral oximetry does not correlate with electroencephalography and somatosensory evoked potentials in determining the need for shunting during carotid endarterectomy. J Vasc Surg.. 2008;48:601-6.

Pennekamp CWA, Moll FL, de Borst GJ. The potential benefits and the role of cerebral monitoring in carotid endarterectomy. Curr Opin Anaesthesiol.. 2011;24:693-7.

Raju I, Fraser K. Anaesthesia for carotid surgery. Anesthesia and Intensive Care Medicine.. 2013;14:208-11.

McCleary AJA, Dearden NMN, Dickson DHD. The differing effects of regional and general anaesthesia on cerebral metabo- lism during carotid endarterectomy. Eur J Vasc Endovasc Surg.. 1996;12:173-81.

McCarthy RJ, Nasr MK, McAteer P. Physiological advanta- ges of cerebral blood flow during carotid endarterectomy under local anaesthesia. A randomised clinical trial. Eur J Vasc Endovasc Surg.. 2002;24:21-521.

AbuRahma AF, Stone PA, Hass SM. Prospective randomized trial of routine versus selective shunting in carotid endarterec- tomy based on stump pressure. YMVA.. 2010;51:1133-8.

Menyhei G, Björck M, Beiles B. Outcome following carotid endarterectomy: lessons learned from a large inter- national vascular registry. Eur J Vasc Endovasc Surg.. 2011;41:735-40.

Weber CF, Friedl H, Hueppe M. Impact of general versus local anesthesia on early postoperative cognitive dysfunction following carotid endarterectomy. GALA Study Subgroup Analy- sis.. 2009;33:1526-32.

De Rango P, Caso V, Leys D. The role of carotide aryrt stenting and carotid endarterectomy in cognitive performance: a systematic review. Stroke.. 2008;39:3116-27.

Heyer EJ, Gold MI, Kirby EW. A study of cognitive dysfunc- tion in patients having carotid endarterectomy performed with regional anesthesia. Anesth Analg.. 2008;107:636-42.

Heyer EJ. Neuropsychological dysfunction in the absence of structural evidence for cerebral ischemia after uncomplicated carotid endarterectomy. Neurosurgery.. 2006;58:474.

Heyer EJ, Sharma R, Rampersad A. A controlled prospec- tive study of neuropsychological dysfunction following carotid endarterectomy. Arch Neurol.. 2002;59:217-22.

5dd296020e8825c42bc63496 rba Articles
Links & Downloads

Braz J Anesthesiol

Share this page
Page Sections