Efeito in vitro de dexmedetomidina na agregação plaquetária
In vitro effect of dexmedetomidine on platelet aggregation
Emine Arzu Kose; Oral Nevruz; Mehtap Honca; Vedat Yildirim
Resumo
Palavras-chave
Abstract
Keywords
Referências
Maze M, Tranquilli W. Alpha-2 adrenoceptor agonists: Defining the role in clinical anesthesia. Anesthesiology. 1991;74:581-605.
Afonso J, Reis F. Dexmedetomidine: current role in anesthesia and intensive care. Rev Bras Anestesiol. 2012;62:118-133.
Bhana N, Goa KL, McClellan KJ. Dexmedetomidine. Drugs. 2000;59:263-268.
Ozkose Z, Demir FS, Panpal K. Hemodynamic and anesthetic advantages of dexmedetomidine, an α2-agonist, for surgery in prone position. Thaku J Exp Med. 2006;210:153-160.
Kerry R, Scrutton MC, Wallis RB. Mammalian platelet adrenoceptors. Br J Pharmac. 1984;81:91-102.
Ardlie NG, McGuiness JA, Garret JJ. Effect on human platelets of catecholamines at levels achieved in the circulation. Atherosclerosis. 1985;58:251-259.
Kottke-Marchant K, Corcoran G. The laboratory diagnosis of platelet disorders: an algorithmic approach. Arch Pathol Lab Med. 2002;126:133-146.
Hjendahl P, Chronos NAF, Wilson DJ. Epinephrine sensitizes human platelets in vivo and in vitro as studied by fibrinogen binding and selectin expression. Arterioscler Thromb. 1994;14:77-84.
Rand ML, Leung R, Packam MA. Platelet function assays. Transfus Apher Sci. 2003;28:307-317.
Aho M, Lehtinen AM, Erkola O. The effect of intravenously administered dexmedetomidine on perioperative hemodynamics and isoflurane requirements in patients undergoing abdominal hysterectomy. Anesthesiology. 1991;74:997-1002.
Jalonen J, Hynynen M, Kuitunen A. Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting. Anesthesiology. 1997;86:331-345.
Virtanen R, Savola J-M, Saano V. Characterization of the selectivity, specifity, and potency of medetomidine as an α2-adrenoceptor agonist. Eur J Pharmacol. 1988;150:9-14.
Winther K, Klysner R, Geisler A. Characterization of human platelet beta-adrenoreceptors. Thromb Res. 1985;40:757-767.
Hjemdahl P, Larsson PT, Wallen NH. Effects of stress and beta-blockade on platelet function. Circulation. 1991;84(^s6):V144-V161.
Grant JA, Scrutton MC. Interaction of selective α-adrenoceptor agonists and antagonists with human and rabbit blood platelets. Br J Pharmacol. 1980;71:121-134.
Kambayashi J-I, Shinoki N, Nakamura T. Prevalence of impaired responsiveness to epinephrine in platelets among Japanese. Thromb Res. 1996;81:85-90.
Von Kanel R, Dimsdale JE. Effects of sympathetic activation by adrenergic infusions on hemostasis in vivo. Eur J Hematol. 2000;65:357-369.
Petidis K, Douma S, Doumas M. The interaction of vasoactive substances during exercise modulates platelet aggregation in hypertension and coronary artery disease. BMC Cardiovasc Disord. 2008;27(8).
Martins CR, Tardelli MA, Amaral JL. Effects of dexmedetomidine on blood coagulation evaluated by thromboelastography. Rev Bras Anestesiol. 2003;53:705-719.
Stump DC, Macfarlane DE. Clonidine and para-aminoclonidine, partial agonists for the alpha2-adrenergic receptor on intact human blood platelets. J Lab Clin. 1983;102:779-787.
Petrusewicz J, Kaliszan R. Human blood platelet alpha adrenoceptor in view of the effects of various imidazol(in)e drugs on aggregation. Gen Pharmacol. 1991;22:819-823.
Hsu CY, Knapp DR, Halushka PV. The effects of alpha adrenergic agents on human platelet aggregation. J Pharmacol Exp Ther. 1979;208:366-370.
Hikasa Y, Abe M, Satoh T. Effects of imidazoline and non-imidazoline alpha-adrenergic agents on canine platelet aggregation. Pharmacology. 1999;58:171-182.
Piletz JE, Sletten K. Nonadrenergic imidazoline-binding sites on human platelets. J Pharmacol Exp Ther. 1993;267:1493-502.